Next Generation Sequencing (NGS) Testing
At One Corp Diagnostics, our Next Generation Sequencing (NGS) testing uses advanced technology to rapidly analyze multiple genes at the same time. This approach can detect genetic variants, including single nucleotide variants (SNVs), insertions, deletions, and copy number variations, that may be associated with inherited or complex diseases.
Through NGS testing, we help clinicians:
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Identify the genetic basis of disease
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Determine hereditary risk factors
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Guide treatment decisions with greater precision
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Support family planning through carrier testing
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Enable earlier detection and intervention
Details
Panels
Cardiopulmonary Panel
Comprehensive genetic testing for inherited cardiovascular and pulmonary disorders, including:
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Cardiomyopathies (dilated, hypertrophic, restrictive)
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Arrhythmia syndromes (e.g., Long QT, Brugada, CPVT)
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Pulmonary hypertension and other hereditary lung diseases
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Genes related to connective tissue disorders affecting the heart and lungs
Comprehensive Immunodeficiency Panel
Evaluates genetic variants associated with both primary and secondary immunodeficiency conditions. This panel can help identify:
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Severe Combined Immunodeficiency (SCID)
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Common Variable Immunodeficiency (CVID)
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Chronic granulomatous disease
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Other rare immune system disorders affecting infection resistance and immune regulation
Comprehensive Neurology Panel
Covers a broad range of neurological and neuromuscular disorders, including:
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Epilepsy and seizure syndromes
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Ataxias and movement disorders
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Neuropathies and myopathies
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Neurodegenerative diseases with known genetic causes
Diabetes Panel
Detects genetic variants linked to various forms of diabetes, including:
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Monogenic diabetes (MODY)
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Neonatal diabetes
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Genetic risk factors for Type 1 and Type 2 diabetes
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Syndromic forms of diabetes associated with other organ involvement
Eye Disorders Panel
Targets genes associated with inherited ophthalmologic conditions, such as:
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Retinitis pigmentosa
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Glaucoma
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Macular degeneration
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Corneal dystrophies
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Optic atrophy
Hereditary Cancer Gene Panel
Identifies inherited mutations in genes that increase cancer risk, including:
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BRCA1/2 (breast and ovarian cancer)
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Lynch syndrome genes (colon and endometrial cancer)
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Genes linked to pancreatic, prostate, melanoma, and other cancers
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Supports personalized cancer screening and prevention strategies
Primary Immunodeficiency Panel
Focused testing for genes associated specifically with primary immune system disorders, including:
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B-cell and T-cell deficiencies
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Phagocyte function defects
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Complement pathway deficiencies
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Immune dysregulation syndromes
Thyroid Genetic Panel
Detects variants related to hereditary thyroid disorders, such as:
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Congenital hypothyroidism
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Autoimmune thyroid disease susceptibility
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Thyroid hormone resistance syndromes
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Thyroid cancer predisposition genes
Specimen Collection & Process
Collection Tubes Used
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Blood, saliva, or buccal swab, depending on panel requirements.
Turnaround Time
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Typically 2–4 weeks from specimen receipt.
Reporting
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Detailed variant analysis
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Pathogenicity classification (ACMG guidelines)
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Clinical interpretation
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Recommendations for follow-up or family testing
Kit Instructions
Included
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Collection tube or saliva kit
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Pre-labeled specimen ID
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Biohazard transport bag
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Test requisition form
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Prepaid return shipping label
Step by Step
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Collect the specimen per kit instructions (blood draw, saliva collection, or cheek swab).
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Label with patient name, DOB, and date/time of collection.
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Place in the provided biohazard bag.
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Complete the requisition form and place it in the pouch.
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Return via prepaid shipping or arranged courier pickup.
FAQs
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Q: Who should consider NGS testing?
A: Patients with a strong family history of certain diseases, early-onset or unexplained conditions, or those whose symptoms suggest a genetic basis.
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Q: Is NGS covered by insurance?
A: Many panels are covered with appropriate medical necessity documentation; check with your provider.
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Q: How accurate are NGS results?
A: Our NGS tests are validated to meet clinical-grade standards, with high analytical sensitivity and specificity.
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Q: Will the results explain my symptoms?
A: NGS can identify genetic contributors to disease, but interpretation should be done with your healthcare provider in the context of your full medical history.
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Q: Can family members be tested?
A: Yes—targeted testing for relatives may be recommended if a pathogenic variant is found.