Toxicology

Toxicology testing plays a vital role in monitoring patient compliance, detecting substance misuse, and guiding treatment plans. At 1 Corp Diagnostics, we combine rapid immunoassay screening with confirmatory testing using liquid chromatography–tandem mass spectrometry (LC-MS/MS) for high accuracy and specificity.

We provide:

Drug Class Screening for rapid preliminary results
Reflex Confirmation for any presumptive positive from the initial screen
Full Confirmation Panels for comprehensive detection of a wide range of substances and metabolites

Details

Initial Drug Screen

Our initial immunoassay drug screen detects:

Amphetamines
Barbiturates
Benzodiazepines
Cocaine
Ethanol (ETOH)
Methadone
Opiates
Oxycodone
Phencyclidine (PCP)
Tetrahydrocannabinol (THC)

Reflex Confirmation

If any drug class in the screen is positive, we automatically perform a targeted LC-MS/MS confirmation for that class to validate results and quantify levels.

Full Confirmation Panel - Analytes

Our comprehensive LC-MS/MS toxicology panel detects and confirms the following:

Barbiturates: Amobarbital, Butalbital, Phenobarbital
Alcohol Metabolites: Ethyl Glucuronide (ETG), Ethyl Sulfate (ETS)
Opiates & Opioids: Codeine, Morphine, Hydrocodone, Hydromorphone, Norhydrocodone, Oxycodone, Oxymorphone, Noroxycodone, 6-Monoacetylmorphine, Methadone, EDDP, Meperidine, Normeperidine, Fentanyl, Norfentanyl, Buprenorphine, Norbuprenorphine, Tapentadol, Tramadol, Desmethyltramadol, Naloxone, Naltrexone, Mitragynine (Kratom)
Benzodiazepines: Alprazolam, Hydroxyalprazolam, Clonazepam, 7-Aminoclonazepam, Diazepam, Nordiazepam, Flunitrazepam, Lorazepam, Temazepam, Oxazepam, Flurazepam, Hydroxytriazolam, Hydroxymidazolam, Zaleplon, Zolpidem, Zolpidem COOH
Stimulants & Related: Amphetamine, Methamphetamine, MDA, MDEA, MDMA, Phentermine, Methylphenidate, Ritalinic Acid
Antidepressants: Amitriptyline, Nortriptyline, Imipramine, Desipramine, Doxepin, Fluoxetine, Sertraline, Venlafaxine
Muscle Relaxants & Sedatives: Carisoprodol, Meprobamate, Cyclobenzaprine, Gabapentin, Pregabalin
Anesthetics & Dissociatives: Ketamine
Other Agents: OPRM1-related opioids, multiple drug metabolites for compliance monitoring

Specimen Collection & Process

Specimen Type

Urine (primary), oral fluid available for specific programs

Turnaround Time

Screening results: Same day or next business day
Confirmation results: 1–3 business days after specimen receipt

Reporting

Clear, easy-to-read reports showing detected analytes, concentrations, and cutoff levels
Positive confirmations include metabolite profiles for prescription compliance assessment

Kit Instructions

Included

Collection cup or oral fluid device, security seal, biohazard transport bag, requisition form, prepaid return label

Step by Step

Collect specimen following chain-of-custody or standard collection protocols.
Secure lid and apply tamper-evident seal.
Label specimen with patient name, DOB, and collection date/time.
Complete requisition form, noting medications reported by patient.
Place specimen in transport bag with paperwork in outer pocket.
Return via prepaid courier or approved pickup.

FAQs

Q: What’s the difference between screening and confirmation?
A: Screening quickly detects drug classes; confirmation uses LC-MS/MS to identify and quantify specific drugs and metabolites.

Q: Do you automatically confirm positives?
A: Yes, through our reflex confirmation protocol.

Q: Can results show if a medication is being taken as prescribed?
A: Yes—metabolite patterns can indicate compliance or possible diversion.

Q: How far back can drugs be detected?
A: Detection windows vary by drug class and patient metabolism, from hours to several days or weeks.

Q: Is testing admissible for legal or compliance programs?
A: Yes—when collected with proper chain-of-custody procedures.